The May-apple or American-mandrake (Podophyllum peltatum) is a rhizomatous, perennial herb, in the Barberry family (Berberidaceae), native to the eastern and central U.S. and southern Ontario & Quebec. In the narrow sense (senso stricto), Podophyllum is a monotypic genus native to North America, but the genus is sometimes treated more broadly to include sixteen other species mostly native to Asia, Japan, Sakhalin, and Taiwan. These other species are otherwise treated as belonging to the genera Diphylleia (3 spp.), Dysosma (12 spp.), and Sinopodophyllum (1 sp. S. hexandrum).
Also, one species of Diphylleia, Umbrella-leaf (Diphylleia cymosa), is native to the Appalachian Mountains of the eastern U.S.
In my garden, leaves and flower buds of my Podophyllum peltatum are currently emerged and expanding. Each mature, fertile stem produces a single white flower, set between two large, palmate leaves. Individual, non-flowering leaves are also produced off the rhizome.
As I only have one clone, and Podophyllum peltatum is largely self-incompatible, it is unlikely the flowers will produce the large red fruit that gives the plant the name 'May-apple'.